• Chronic Bronchitis

    Chronic bronchitis is a subset of Chronic Obstructive Pulmonary Disease (COPD).

    Chronic bronchitis manifests itself as chronic inflammation of the bronchial walls, cough and increased production of mucus. In addition, chronic bronchitis may or may not present with obstruction/partially blocked airways due to swelling and excess mucus in the bronchi, or shortness of breath (dyspnea).

    Prevalence (US, Europe, Canada)

    In the United States of America, there are an estimated 12.7 – 14.7 million Americans with COPD1, and in 2011 approximately 10 million Americans sought medical attention for chronic bronchitis2. In Europe, there are approximately 23 million people with COPD3, and approximately 14.3 million people with COPD in Germany, France, Belgium, Austria, Netherlands, Spain, Italy, UK and Ireland4.

    The population of chronic bronchitis patients is relatively steady, growing at approximately 1% per year5. There is no cure for chronic bronchitis.

    Treatment options

    The standard of care for chronic bronchitis patients is pharmaceuticals, many of which are designed to address dyspnea associated with inflammation – LABA (long acting beta agonists) and ICS (Inhaled corticosteroids); and/or cough. Physicians may prescribe bronchodilators to patients as a way to provide relief during sudden breathing problems, such as acute bronchospasm.

    Patients often seek emergent medical attention when they are experiencing exacerbations, either through a physician office visit or in the emergency department (ED). Patients with moderate exacerbations are often treated with an oral corticosteroid medication to reduce swelling in the airways. Patients with severe exacerbations are often hospitalized for supportive oxygen therapy until their exacerbation is reduced.

    Chronic bronchitis may lead to inflammation of the airway lining, excess mucus production, and damage to the cilia.

     

    The RejuvenAir System is currently under clinical investigation and is not commercially available.

    1 American Lung Association, Trends in COPD: Morbidity and Mortality, Table 3. http://www.lung.org/finding-cures/our-research/trend-reports/copd-trend-report.pdf
    2 American Lung Association, Trends in COPD: Morbidity and Mortality, Table 3. http://www.lung.org/finding-cures/our-research/trend-reports/copd-trend-report.pdf
    3 Health at a Glance: Europe (2012 and 2014 reports) http://www.oecd-ilibrary.org/social-issues-migration-health/health-at-a-glance-europe-2012_9789264183896-en
    4 European COPD Coalition http://www.copdcoalition.eu/about-copd/prevalence
    5 American Lung Association, Trends in COPD: Morbidity and Mortality, Table 3. http://www.lung.org/finding-cures/our-research/trend-reports/copd-tren