• RejuvenAir® Technology

    The RejuvenAir® System consists of a console and a catheter. The console stores liquid nitrogen and controls the release of liquid nitrogen during a procedure. The catheter is inserted through a bronchoscope and sprays droplets of liquid nitrogen on treatment sites within the lungs. Each spray is referred to as a Metered Cryospray™.

    RejuvenAir Console and RejuvenAir Catheter Kit on a bronchoscope

    The Metered Cryosprays are designed to cryoablate abnormal surface epithelium and overgrown mucous-producing goblet cells and adjacent submucosa up to a depth of 0.5 mm.

    The Metered Cryosprays are delivered to the primary locations where cough receptors, goblet cells and mucous glands are located.


    • Cough receptors are centrally located, being found in the trachea, main carina, branching points of large airways, and more distal smaller airways1.

    • Mucus is produced by goblet cells and mucous glands, which are situated in the epithelium and submucosa, with the highest volume/surface area occurring in the trachea to the lobar bronchi2.




    The RejuvenAir® System is currently under clinical investigation and is not commercially available.

    1 Polverino, et al, Anatomy and neuro-pathophysiology of the cough reflex arc; Multidisciplinary Respiratory Medicine 2012, 7:5

    2 Rogers, Airway goblet cells: responsive and adaptable front-line defenders, Eur Respir J, 1994, 7, 1690–1706